If i was directing of a 2010 version movie of the Of Mice and Men  it would be diffrent with better characters. For Curley's wife i would use Angelina Jolie because she is a very good actress and she would be good at sounding just like Curley's wife with the southeren accent!. 

For Lennie i would use Will Ferrell, For George i would use Brad Pitt, for Slim i would use Zac Efron,for Curley i would use Grenier, That would be my cast!.